Atypical Glandular Cells (AGC)

Handout

The Pap test your healthcare provider recently performed has shown some abnormal changes of the cervix called Atypical Glandular Cells or AGC. AGC may arise from the endocervix (glandular portion of the cervix) or the endometrium (uterine lining tissue). Glandular cells are mucus producing cells found in the endocervical canal (opening in the center of the cervix) or in the lining of the uterus. AGC is when the glandular cells do not appear completely normal. Although AGC is an abnormal result that requires additional follow up, it is important to understand that a diagnosis of AGC does not mean that you necessarily have cervical or uterine cancer.

Pap Test Background Information

The Pap test (sometimes called a Pap smear) is a way to examine cells collected from the cervix (the lower, narrow end of the uterus). The main purpose of the Pap test is to find abnormal cellular changes that may arise from cervical cancer or before cancer develops. A Pap test and pelvic exam are important parts of a woman’s routine healthcare because they can detect abnormalities that may lead to invasive cancer of the cervix. These abnormalities can be treated before cancer develops. Most invasive cancers of the cervix can be prevented if women have Pap tests regularly. Also, as with many types of cancer, cancer of the cervix is more likely to be treated successfully if it is detected early. Women should talk with their healthcare provider about when and how often they should have a Pap test. Current general guidelines recommend that women have a Pap test at least once every three years, beginning about years after they begin to have sexual intercourse, but no later than age 21. About 55 million Pap tests are performed each year in the U.S. Of these, approximately 3.5 million (or 6%) are abnormal and require medical follow-up.

Follow-up and Treatment Options

Colposcopy:
Your healthcare provider may decide to perform an additional test called a colposcopy. In this procedure, an instrument similar to a microscope is inserted through the vagina and used to view the cervix directly. Your healthcare provider will be able to see the surface of the cervix clearly during the procedure and will look for any abnormal areas.

Biopsy:
If areas of abnormal cells are seen during the colposcopy, your healthcare provider may biopsy (remove a small tissue sample) and send it to a laboratory for study under a microscope. Often, multiple areas of the cervix are biopsied during the procedure. While a Pap test is a screening test, a biopsy is a diagnostic test and will provide a definitive diagnosis.

Endocervical Curettage (ECC):
In this procedure your healthcare provider will scrape cells from the wall of your cervical canal with a small spoonshaped tool called a curette. The cells are then sent to a laboratory and studied for abnormal changes. ECC is often performed with a biopsy. If the lab finds abnormal cells that have a high chance of becoming cancer, further treatment is needed.

Endometrial Biopsy:
If clinically indicated, your healthcare provider may also decide to obtain a tissue sample from the endometrium, the lining of the uterine cavity. A thin tube is inserted through the cervix into the uterus, and gentle scraping and suction are used to remove the sample.

Loop Electrosurgical Excision Procedure (LEEP):
Your healthcare provider may use an electric loop to remove abnormal tissue from your cervix. The tissue sample is then sent to a laboratory for further examination. The cells that grow back during the healing process are usually normal and healthy.

Cone Biopsy:
Your healthcare provider may remove a cone-shaped wedge of tissue from the opening of the cervix. The tissue is then sent to a laboratory for further examination. The cells that grow back during the healing process are usually normal and healthy.

Questions to Ask Your Healthcare Provider
  • Is this diagnosis going to progress into something more severe?
  • What type of follow up do you suggest and why?
  • What are the potential risks or side effects to this option?
  • When do you recommend a repeat Pap test?
Sources for Additional Information

The content of this web page and corresponding downloadable handout is provided to you as general information and not intended as a diagnosis. Please consult with your personal physician regarding the essential details about your condition. Updated 12/2013.

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